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Monday, November 3, 2008

Definition of Mesothelioma

Mesothelioma is a form of cancer that is almost always caused by previous exposure to asbestos. In this disease, malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the heart, the pericardium (a sac that surrounds the heart) or tunica vaginalis.

A malignant tumor of the mesothelium. The mesothelium is the thin lining on the surface of the body cavities and the organs that are contained within them. Most mesotheliomas begin as one or more nodules that progressively grow to form a solid coating of tumor surrounding the lung, abdominal organs, or heart.

Mesothelioma most commonly occurs in the chest cavity and is associated with exposure to asbestos in up to 90% of cases. It has been shown that some asbestos fibers that are inhaled quickly work their way through the lung tissue and into the chest (pleural) cavity. Asbestos fibers that are swallowed have been shown to penetrate the wall of the intestine and appear in the abdominal (peritoneal) cavity.

The risk of mesothelioma increases with the intensity and duration of exposure to asbestos. It is debatable whether or not there is any safe exposure level. Mesothelioma typically does not occur for 20 to 50 years following exposure to asbestos. Some forms of asbestos, particularly crocidolite fibers, are more likely to cause mesotheliomas. There is also evidence that mesotheliomas may be caused by other agents including radiation, viruses, and man-made mineral fibers. There is no relationship to smoking.

Mesothelioma is currently difficult to treat in most cases and survival beyond two years is unusual.

Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. Washing the clothes of a family member who worked with asbestos can also put a person at risk for developing mesothelioma. Unlike lung cancer, there is no association between mesothelioma and smoking. Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see asbestos and the law).

The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.

Definitions of MESOTHELIOMA on the Web:

* a form of cancer linked to asbestos exposure that occurs in the sac lining of the chest (pleural mesothelioma) or abdomen (peritoneal mesothelioma ...
www.belluckfox.com/mesothelioma/mesothelioma_glossary.html

* a tumor of the mesothelium, that can be benign (localized) or malignant (diffusely spread), and that is most commonly caused by the ingestion of asbestos particles.
www.mesotheliomacancerfile.org/mesothelioma_glossary.htm

* Mesothelioma is a cancer of the cells that make up the lining around the outside of the lungs and inside of the ribs (pleura), or around the abdominal organs (peritoneum). It is usually fatal.
www.brooks-law.com/CM/Custom/Definitions.asp

* Malignant mesothelBoldioma, a rare form of cancer, is a disease in which cancer (malignant) cells are found in the sac lining the chest (the pleura) or abdomen (the peritoneum). Most people with malignant mesothelioma have worked on jobs where they breathed a
www.texascancerclinic.com/cancerinfo/glossary.cfm

* A type of cancer caused by exposure to asbestos.
www.larrycurtislawfirm.com/dictionary.php

* (mez-uh-thee-lee-YOH-muh) — A tumor in the lining of the chest or abdomen (stomach area).
www.cdc.gov/cancer/lung/glossary/

* "A rare cancer that occurs in the thin layer of tissue that covers the majority of your internal organs (mesothelium)." (Mayo Clinic, 2007)
www.csa.com/discoveryguides/asbestos/gloss.php

* A cancer most often caused by exposure to asbestos, mesothelioma is a deadly medical condition in which cells mutate to form cancers on the mesothelium (most often of the lungs.
www.asbestos.com/glossary/m.php

* A kind of cancer that originates in the pleura, that is, the layer of cells that line the outer surface of the lung. This cancer is usually considered a tumor of the pleura and not a type of lung cancer.
www.healthtalk.com/lungcancer/diseasebasics07.cfm

* Cancer involving the pleura (the membranes that cover the lungs).
www.johnshopkinshealthalerts.com/reports/lung_disorders/927-1.html

* Malignant spreading tumour of the mesothelium of the pleura, pericardium, or peritoneum, arising as a result of the presence of asbestos fibres. ...
www.work.med.ed.ac.uk/hew/tox/glossall.html

* a cancer of the lining of the lungs, chest and stomach caused by inhalation of asbestos dust and fibers or asbestos exposure
www.mesoblog.org/mesothelioma-glossary.php

* A cancer of cells similar to those forming the lining of the lungs, heart, the abdominal cavity and its organs.
www.dva.gov.au/health/hlthstdy/validation/glossary.htm

* A cancer in the tissue lining of certain organs, including the heart and lung, that may be attributed to long-term inhalation of asbestos.
www.lung.com/dictionary/lung_larynx-ozone.php

* A malignant tumor covering the lining of the lung and often associated with asbestos exposure.
www.mesothelioma-treatment-2day.com/Mesothelioma_Medical_Terms.html

* A malignant tumor of mesothelium caused by the inhalation of asbestos
quizlet.com/print/15664/

* a tumor or tumors affecting the lining of the chest or abdomen. Most cases of mesothelioma are malignant, and are caused by exposure to asbestos. A small number of cases of mesothelioma are benign, or non-cancerous. (See also malignant mesothelioma),
mesotheliomaattorneyalliance.com/about-mesothelioma/glossary.htm

* A tumor in the lining of the lungs. Mesothelioma is linked almost exclusively to asbestos exposure.
www.lungcancersurvival.info/a-lung-cancer-glossary-d.php

* A rare cancer, usually found in those exposed to asbestos, in the form of a malignant tumor in the mesothelium of the lungs and or abdomen. Symptoms of this incurable disease are persistent coughing or coughing of blood, chest or abdomen pain, fatigue, and weight loss.
www.mesotheliomalawyersfyi.com/glossary.html

* A rare tumor which develops within the thin protective lining between organs
treatingmesothelioma.org/

* a form of carcinoma of the mesothelium lining lungs or abdomen or heart; usually associated with exposure to asbestos dust
wordnet.princeton.edu/perl/webwn

* Mesothelioma is a form of cancer that is almost always caused by previous exposure to asbestos.United States Department of Health and Human Services. In this disease, malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. ...
en.wikipedia.org/wiki/Mesothelioma

* An uncommon malignant tumour of the mesothelium, usually of the lungs after exposure to asbestos
en.wiktionary.org/wiki/mesothelioma

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